oncologie, is aimed to the publication of high quality original research articles or review papers with an active interest in vivo or vitro study of cancer biology. (2024)

Open Access

ARTICLE IN FRENCH

Oncologie, Vol.24, No.4, pp. 605-612, 2022, DOI:10.32604/oncologie.2022.024558
Abstract A retrospective observational study carried out in the United States showed a decrease in survival in patients treated for breast, prostate, lung and colorectal cancer with complementary medicines. We verified this result with aFrench population of consecutive 636 patients diagnosed with the same cancer and treated with oral chemotherapy in an hospital for three years. An interview by a pharmacist before the administration of oral chemotherapywas made to identify the complementary medicines used by the patients. We compared the overall survivalusing a log-rank test by stratifying the groups (number of cancers, number of comorbidities, age, sex). The… More >

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Open Access

REVIEW

Advances in Targeted Therapy Against Driver Mutations and Epigenetic Alterations in Non-Small Cell Lung Cancer

Oncologie, Vol.24, No.4, pp. 613-648, 2022, DOI:10.32604/oncologie.2022.027545
Abstract The incidence and mortality of lung cancer rank top three of all cancers worldwide. Accounting for 85% of the total number of lung cancer, non-small cell lung cancer (NSCLC) is an important factor endangering human health. Recently, targeted therapies against driver mutations and epigenetic alterations have made encouraging advances that benefit NSCLC patients. Druggable driver mutations, which mainly occur in EGFR, KRAS, MET, HER2, ALK, ROS1, RET and BRAF, have been identified in more than a quarter of NSCLC patients. A series of highly selective mutant targeting inhibitors, such as EGFR tyrosine kinase inhibitors and KRAS inhibitors, have been well… More >

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Open Access

REVIEW

Epidemiology of Breast Cancer

Oncologie, Vol.24, No.4, pp. 649-663, 2022, DOI:10.32604/oncologie.2022.027640
Abstract All over the world, the most common malignancy in women is breast cancer. Breast cancer is also a significant factor of death in women. In 2020, approximately 2.3 million cases of breast cancer were newly diagnosed in women globally, and approximately 685,000 people died. Breast cancer incidence varies by region around the world, but it is all increasing. According to the current morbidity and mortality trend of breast cancer, it is estimated that by 2030, the number of incidence and deaths of breast cancer will reach 2.64 million and 1.7 million, respectively. The age-standardized incidence rate was 66.4/100,000 in developed… More >

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Open Access

REVIEW

The Emerging Role of Lymphocyte Activation Gene 3 in the Cancer Immunotherapy

Oncologie, Vol.24, No.4, pp. 665-678, 2022, DOI:10.32604/oncologie.2022.023641
（This article belongs to the Special Issue: Cancer Immunotherapy)
Abstract The emergence of tumor immunotherapy, especially immune checkpoint inhibitors (ICIs), has brought new life tocancer treatment, and ICIs can effectively treat various tumors. Among the immune anti-cancer therapies, PD-1 isundoubtedly the hot target after CTLA-4, but due to the ineffectiveness of PD-1 in treating certain tumors,researchers have shifted their focus to other combination targets, such as LAG-3, TIM3, IDO-1, etc. One of thesepromising targets is LAG-3, a target with multiple clinical trials, which has increasingly shown to be an inhibitoryco-receptor that plays a vital role in autoimmunity, cancer immunity, and anti-infection immunity. Immune combination therapy… More >

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Open Access

REVIEW

Ferroptosis’s Role in Genitourinary System Cancer

Oncologie, Vol.24, No.4, pp. 679-691, 2022, DOI:10.32604/oncologie.2022.025705
（This article belongs to the Special Issue: Ferroptosis in the Occurrence and Treatment of Cancer)
Abstract A cell is the basic unit of life, and death is inevitable for any cell. However, cancer cells that deviate from the normal track can resist death and survive. Ferroptosis is recently discovered as a modulated cell death different from other known forms of cell death in morphology, biochemistry, and genetics. It is characterized by iron-dependent lipid peroxidation regulated by various metabolic pathways. The incidence and mortality of genitourinary system cancer have been increasing recently. Although clinical practice therapy techniques have improved, no plan with a positive prognosis has been identified. For the therapy of cancer, ferroptosis opens up new… More >

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Open Access

ARTICLE

The Neurosurgical Challenge of Primary Central Nervous System Lymphoma Diagnosis: A Multimodal Intraoperative Imaging Approach to Overcome Frameless Neuronavigated Biopsy Sampling Errors

Oncologie, Vol.24, No.4, pp. 693-706, 2022, DOI:10.32604/oncologie.2022.025393
Abstract Background: Intracranial lymphoma remains a challenging differential diagnosis in daily neurosurgical practice. We analyzed our early experience with a surgical series of frameless neuronavigated biopsies in PrimaryCNS Lymphomas (PCNSLs), highlighting the importance of using an intraoperative combined imaging protocol (5-ALA fluorescence, i-CT and ¹¹C-MET-PET) to overcome potential targeting errors secondary totumor volume reduction after corticosteroid therapy. Materials and Methods: All patients treated for PCNLSsat our center in a 24-month period (1/1/2019 to 31/12/2020) were analyzed. Our cohort included 6 patients(4 males), with a median age of 67 years (59–82). A total of 45 samples were evaluated… More >

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Open Access

ARTICLE

Nimotuzumab Combined with Neoadjuvant or Induction Chemotherapy for Head and Neck Squamous Cell Carcinoma: A Retrospective Study

Oncologie, Vol.24, No.4, pp. 707-716, 2022, DOI:10.32604/oncologie.2022.027023
Abstract Objective: To assess the efficacy and toxicity of nimotuzumab combined with neoadjuvant or induction chemotherapy for head and neck squamous cell carcinoma (HNSCC). Methods: Patients received intravenous nimotuzumab (400 mg, weekly for 1–3 weeks) combined with chemotherapy (5-fluorouracil/pacl*taxel/docetaxel +nedaplatin/cisplatin for 1–2 cycles), prior to definitive surgical resection, radiotherapy or other treatments. Theprimary endpoint was the objective response rate (ORR). The secondary endpoints were tumor downstaging,complete response rate (CRR), partial response rate (PRR), disease control rate (DCR), R0 resection rate, pathological complete response (pCR), larynx preservation rate, overall survival (OS), progression-free survival (PFS),and safety. Results: A total… More >

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Open Access

ARTICLE

Study on the Value of Ultrasound Elastography Combined with Plasma miRNA Expression in the Early Detection of Breast Cancer

Oncologie, Vol.24, No.4, pp. 717-727, 2022, DOI:10.32604/oncologie.2022.026998
（This article belongs to the Special Issue: Biomarkers for Breast Cancer Diagnosis and Treatment Selection: from Basic Research to Practice)
Abstract Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity and mortality areincreasing each year, due to the lack of specific clinical symptoms in the early stage of BC, and the lack of diagnosticmethods for early breast cancer. Therefore, identifying an effective diagnostic method for early BC has become urgent.Materials and Methods: Breast lesions with a histological diagnosis that were examined by ultrasonic elastography(UE) in our department from June 2020 to December 2021 were reviewed. qRT-PCR was performed to measurethe expression levels of miR-144-5p and miR-26b-5p in the plasma of… More >

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ARTICLE

PD-1 Relevant Genes Predict the Prognosis of Breast Cancer and Their Prediction Effect in Tumor Response to Immunotherapy

Oncologie, Vol.24, No.4, pp. 729-742, 2022, DOI:10.32604/oncologie.2022.026118
（This article belongs to the Special Issue: Biomarkers for Breast Cancer Diagnosis and Treatment Selection: from Basic Research to Practice)
Abstract Background: Immunotherapy is becoming a powerful approach in the treatment of breast cancer. However, highresponse rates in the majority of breast cancer patients have yet to be achieved. Materials and Methods: Based on publicdata sources, we identified 22 genes that are correlated with PD-1 expression as well as differentially expressed betweentumor tissues and normal tissues, and high expression of all the key genes was correlated with a superior survival outcome.Using the least absolute shrinkage and selection operator Cox regression model, a risk score was constructed. Results: Amultivariate Cox analysis showed that the constructed risk score… More >

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Open Access

ARTICLE

Research on Clinical Effectiveness of Aspirin for Treating Breast Cancer and Cell Protein Biomarkers on Aspirin Treatment in Drug-Resistant Estrogen Receptor-Positive Breast Cancer Cells

Oncologie, Vol.24, No.4, pp. 743-768, 2022, DOI:10.32604/oncologie.2022.025419
（This article belongs to the Special Issue: Biomarkers for Breast Cancer Diagnosis and Treatment Selection: from Basic Research to Practice)
Abstract Background: Aspirin (ASA) has been reported to have an antitumor effect but the role of ASA in the prevention and treatment of breast cancer (BC) is still controversial. This study aimed to identify clinical effectiveness of ASA in the treatment of BC and explore the antitumor target proteins of ASA that may be involved in overcoming tamoxifen resistance in estrogen receptor (ER)-positive BC cells. Materials and Methods: Randomized controlled trials (RCTs) of ASA in the treatment of BC were queried from the databases, including PubMed, Web of Science, Cochrane Library, WanFang, and Chinese National Knowledge Infrastructure. According to the quality… More >

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Open Access

ARTICLE

Angiogenic Gene PTK2 is a Potential Biomarker of Gestational Diabetes Mellitus and is Significantly Associated with Breast Cancer Immune Infiltration

Oncologie, Vol.24, No.4, pp. 769-787, 2022, DOI:10.32604/oncologie.2022.026248
Abstract Background: Gestational diabetes mellitus (GDM) affects the health of numerous women around the world. Arecent study has shown that GDM is associated with an increased incidence of cancer. In this study, we aimedto explore the possible shared mechanisms and potential common therapeutic targets between GDM and cancer.Methods: The limma package was used to identify differentially expressed genes (DEGs) in GDM. The Cytoscapeplugin cytoHubba was used to screen hub genes. The CIBERSORT algorithm was used to explore the correlationbetween hub genes and immunity. Cox regression analysis was used to assess the relationship between proteintyrosine kinase… More >

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Open Access

ARTICLE

Identification of Circular RNA hsa-circ-0006969 as a Novel Biomarker for Breast Cancer

Oncologie, Vol.24, No.4, pp. 789-801, 2022, DOI:10.32604/oncologie.2022.026589
（This article belongs to the Special Issue: Biomarkers for Breast Cancer Diagnosis and Treatment Selection: from Basic Research to Practice)
Abstract Background: To investigate the characteristics of circular RNA hsa-circ-0006969 in breast cancer and identify itas a novel biomarker for breast cancer. Methods: Three breast cancer (BC) patient tissues were selected to perform human circRNA microarray analysis. GeneSpring 13.0 (Agilent) software was applied for analyzing the data.Another 116 BC patients were recruited for verification. Hsa-circ-0006969 was found as a potential circRNA forBC diagnostic biomarker. The structure of hsa-circ-0006969 was predicted by circPrimer1.2 software. MiRandav3.3, RNA hybrid 2.1, and Cytoscape 3.6.0 were used for predicting the networks of circRNA-miRNA. T-test,Curve regression, and ROC analysis were applied to… More >

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Open Access

ARTICLE

A Metabolism-Related Gene Signature Predicts the Prognosis of Breast Cancer Patients: Combined Analysis of High-Throughput Sequencing and Gene Chip Data Sets

Oncologie, Vol.24, No.4, pp. 803-822, 2022, DOI:10.32604/oncologie.2022.026419
（This article belongs to the Special Issue: Biomarkers for Breast Cancer Diagnosis and Treatment Selection: from Basic Research to Practice)
Abstract Background and Aim: Hundreds of consistently altered metabolic genes have been identified in breast cancer(BC), but their prognostic value remains to be explored. Therefore, we aimed to build a prediction model basedon metabolism-related genes (MRGs) to guide BC prognosis. Methods: Current work focuses on constructing anovel MRGs signature to predict the prognosis of BC patients using MRGs derived from the Virtual MetabolicHuman (VMH) database, and expression profiles and clinicopathological data from The Cancer Genome Atlas(TCGA) and Gene Expression Omnibus (GEO) databases. Results: The 3-MRGs-signature constructed by SERPINA1, QPRT and PXDNL was found to be an… More >

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ARTICLE

RCN3 Expression Indicates Prognosis in Colorectal Cancers

Oncologie, Vol.24, No.4, pp. 823-833, 2022, DOI:10.32604/oncologie.2022.025411
Abstract Background: Reticulocalbin 3 (RCN3) has been associated with several malignancies. However, its role in colorectal cancer (CRC) remains controversial. Thus, this study aimed to investigate the role of RCN3 in CRC prognosis. Methods: The clinical significance of RCN3 expression in CRC was evaluated in a large cohort of483 patients. Normal tissues, carcinoma, para-carcinoma, adenoma, and metastatic tissues were evaluated byimmunohistochemistry. We investigated the association between RCN3 expression and CRC occurrence intumors and other tissues. Prognostic factors were also evaluated by Kaplan-Meier survival analysis and theCox regression model. Results: RCN3 was significantly overexpressed in CRC and metastatic… More >

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ARTICLE

Comprehensive Analysis of the Expression and Clinical Significance of a Ferroptosis-Related Genome in Ovarian Serous Cystadenocarcinoma: A Study Based on TCGA Data

Oncologie, Vol.24, No.4, pp. 835-863, 2022, DOI:10.32604/oncologie.2022.026447
（This article belongs to the Special Issue: Ferroptosis in the Occurrence and Treatment of Cancer)
Abstract Background: Epithelial ovarian cancer (EOC) is the deadliest malignancy among the gynecologic tumors, and ovarian serous cystadenocarcinoma (OV) is the dominant histological type. Ferroptosis is a novel iron-dependent, programmed form of cell death, and agents that trigger ferroptosis may constitute potential anti-cancer therapies.Materials and Methods: We herein extracted the genes that participate in the process of ferroptosis from the onlineFerrDb database to create a ferroptosis-related genome (FRG), and then comprehensively analyzed the relationshipbetween the mRNA expression of each gene and the clinicopathologic features of The Cancer Genome Atlas(TCGA)-OV cohort. Results: We found that most of the… More >

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Open Access

ARTICLE

Racial Disparities in Clinical Features and Survival Outcomes among Patients with Pancreatic Neuroendocrine Tumor: A Contemporary SEER Database Analysis

Oncologie, Vol.24, No.4, pp. 865-895, 2022, DOI:10.32604/oncologie.2022.025447
Abstract Objective: The characteristics of clinical features and prognoses among patients with different racial backgroundshave not been clearly studied. We thus investigated the clinical characteristics and overall survival (OS) differences among Asian, White, and Black patients with pancreatic neuroendocrine tumors (pNETs). Materialsand Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patientswith pNETs between 1983 and 2015. We performed univariable (UVA) and multivariable logistic regression(MVA) to assess the association between variables and race category. A Kaplan-Meier (KM) plot was used to calculate the OS rates. The Cox proportional hazard regression was used to… More >

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Open Access

ARTICLE

MiR-145-5p Suppresses Hepatocellular Carcinoma Progression by Targeting ABHD17C

Oncologie, Vol.24, No.4, pp. 897-912, 2022, DOI:10.32604/oncologie.2022.025693
Abstract Background: MicroRNA-145-5p (miR-145-5p) reportedly inhibits hepatocellular carcinoma (HCC) by targetingARF6, SPATS2, CDCA3, KLF5, and NRAS, indicating that miR-145-5p plays an important role in the occurrenceand development of HCC by regulating the expression of various genes. In this study, we aimed to explore noveldownstream targets of miR-145-5p and elucidate the potential mechanism of miR-145-5p in HCC. Materials andMethods: A bioinformatics analysis was performed to determine the clinical significance of miR-145-5p andalpha/beta hydrolase domain-containing protein 17C (ABHD17C) in patients with HCC. The ability of Hep3Bcells to proliferate, migrate, and invade was examined after overexpression of miR-145-5p… More >

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ARTICLE

Expression and Clinical Significance of ACTA2 in Osteosarcoma Tissue

Oncologie, Vol.24, No.4, pp. 913-925, 2022, DOI:10.32604/oncologie.2022.026296
Abstract Objective: To investigate the expression of alpha–smooth muscle actin (ACTA2) in osteosarcoma tissues and itsrelationship with prognosis. Methods: Prognostic analysis of lung metastasis–related genes in osteosarcoma usingthe TCGA database. Single-cell sequencing detected the expression of ACTA2 in 11 osteosarcoma tissues. Paraf-fin-embedded tissues of 74 osteosarcoma patients treated at the Sixth People’s Hospital of Shanghai Jiao TongUniversity from 2014 to 2019 were collected, and tissue microarrays were prepared. ACTA2 expression wasdetected and scored by immunohistochemistry. According to the median value of the ACTA2 histochemicalscore, 74 patients were divided into two groups, the high-expression group and… More >

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Open Access

CASE REPORT

Multiple Recurrence of Primary Orbital Synovial Sarcoma: Report of Two Cases and Literature Review

Oncologie, Vol.24, No.4, pp. 927-935, 2022, DOI:10.32604/oncologie.2022.026720
Abstract Synovial sarcoma (SS) is typically an aggressive malignant soft tissue tumor that mostly affects adolescents and young adults. It is extremely rare in orbit and carries a high risk of recurrence and metastasis, posing a challenge to ophthalmologists in diagnosing and managing. We present two primary orbital synovial sarcoma cases with unilateral exophthalmos and limited motility. Both male patients underwent reoperation in our hospital since tumor recurrence; the pathologic diagnoses were biphasic type and occult type, respectively. Both cases were positive for EMA and CK, and SOX-9 and INI-1 were newly discovered immune markers. Fluorescence in situ hybridization analysis (FISH)… More >

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CASE REPORT

Differential Diagnosis between Primary Intracranial Melanoma and Cerebral Cavernoma in Crohn’s Disease: A Case Report and Literature Review

Oncologie, Vol.24, No.4, pp. 937-942, 2022, DOI:10.32604/oncologie.2022.027155
Abstract Primary intracranial melanomas are rare, with a challenging diagnosis based only on clinical and imaging features. The authors described the case of an intracerebral right parieto-temporal melanoma mimicking a cavernoma in a patient affected by Crohn’s disease. A 67-year-old female patient with Crohn’s disease and small bowel stenosis was hospitalized for surgical removal of the terminal ileum and latero-lateral ileo-colic anastomosis. During postoperative week 1, the patient developed psychom*otor agitation followed by altered consciousness. An urgent brain CT showed a right intracerebral parieto-temporal hemorrhage with intralesional calcifications. The patient underwent a decompressive craniectomy with hematoma drainage and a complete resection… More >

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